Triethylamine → HCID 178472718, Verbindung

HRID 616359Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 616359
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][NH:6][CH2:7][CH:8]([O:10][CH3:11])[CH3:9])[CH3:2].C(N(CC)CC)C.[N:20]#[N:21].[CH3:22][O:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][C:33]=1[O:34][CH3:35])[CH:30]=[C:29]([S:36]([NH:39][C@H:40]([C:48](Cl)=[O:49])[CH2:41][CH2:42][CH2:43][NH:44][C:45](=[NH:47])[NH2:46])(=[O:38])=[O:37])[CH:28]=[CH:27]2>C(Cl)(Cl)Cl>[N:20]#[N:21].[CH2:1]([O:3][C:4](=[O:12])[CH2:5][N:6]([C:48](=[O:49])[C@H:40]([CH2:41][CH2:42][CH2:43][NH:44][C:45](=[NH:46])[NH2:47])[NH:39][S:36]([C:29]1[CH:28]=[CH:27][C:26]2[C:31](=[CH:32][C:33]([O:34][CH3:35])=[C:24]([O:23][CH3:22])[CH:25]=2)[CH:30]=1)(=[O:38])=[O:37])[CH2:7][CH:8]([O:10][CH3:11])[CH3:9])[CH3:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 20369646N-(2-methoxypropyl)glycine ethyl esterHCID 178486633HCID 178486633, Verbindung

Produkt 1

HCID 178472718HCID 178472718, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 1.3 g of N-(2-methoxypropyl)glycine ethyl ester and 1.7 ml of triethylamine in 50 ml of chloroform, which was cooled in an ice-salt bath, was added in portions N2 -(6, 7-dimethoxy-2-naphthylsulfonyl)-L-arginyl chloride which was obtained in Example 3. The reaction mixture was stirred overnight at room temperature. At the end of this period, 50 ml of chloroform was added and the chloroform solution was washed twice with 50 ml of saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated in vacuo. The oily residue was washed with ether to give 2.4 g of powdery N2 -(6, 7-dimethoxy-2-naphthylsulfonyl)-L-arginyl-N-(2-methoxypropyl)glycine ethyl ester.

Aufarbeitung

  1. customwas obtained in Example 3
  2. washthe chloroform solution was washed twice with 50 ml of saturated sodium chloride solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated in vacuo
  5. washThe oily residue was washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-5e4b51a86e2340dda22be4e0365cbc5b
Quelldatensatz
uspto-grants-1978_02
Patentnummer
US04073892

Notizen zur Reaktion

Wird geladen…