Formaldehyde → 2-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

HRID 616386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 616386
[CH2:1]([CH:5]([C:14]#[N:15])[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])[CH2:2][CH2:3][CH3:4].[CH2:16]=[O:17].[OH-].C([N+](CC)(CC)CC)C1C=CC=CC=1>N1C=CC=CC=1>[C:14]([C:5]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:16][OH:17])#[N:15]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 74601Benzyltriethylammonium hydroxideHCID 123432572-(2,4-Dichlorophenyl)hexane nitrile

Produkt 1

HCID 233399042-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To an ice cold stirred solution of α-n-butyl-2,4 -dichlorobenzyl cyanide (5g., 0.02 mole) in 20 ml. of pyridine containing a suspension of paraformaldehyde (2.4g., 0.08 mole is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 16 hours. The reaction mixture poured into 300 ml. of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 5.6g. of a thick oil, which is identified by nmr.

Aufarbeitung

  1. addition, 0.08 mole is added 1 ml
  2. additionThe reaction mixture poured into 300 ml
  3. extractionof water and extracted with ether
  4. washThe combined ether extracts are washed with water, saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is evaporated
  7. customto give 5.6g

Quellen und Nachweise

ORD-Eintrag
ord-ae715a1f99aa47f889709b282b115d35
Quelldatensatz
uspto-grants-1978_02
Patentnummer
US04073921

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