Pyridine → 4-Methoxy-5-(2-methoxyethoxy)-(3-nitrophenyl)aminobenzamide

HRID 61664

Reaktionsgleichung

Reaktionsgleichung von HRID 61664
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1C=CC=CC=1.[N+:24]([C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=1)C(Cl)=O)([O-:26])=[O:25]>C(Cl)(Cl)Cl>[CH3:12][O:11][C:9]1[C:8]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([NH:1][C:34]2[CH:33]=[CH:29][CH:28]=[C:27]([N+:24]([O-:26])=[O:25])[CH:35]=2)[CH:10]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 8495Benzoyl chloride, 3-nitro-HCID 593619522-Amino-4-methoxy-5-(2-methoxyethoxy)benzamide

Produkt 1

HCID 668250844-Methoxy-5-(2-methoxyethoxy)-(3-nitrophenyl)aminobenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a mixture of 2-amino-4-methoxy-5-(2-methoxyethoxyl)benzamide (1.78 g, 7.40 mmol) and pyridine (2.40 mL, 29.6 mmol) in CHCl3 (40 mL) was added 3-nitrobenzoyl chloride (1.44 g, 7.8 mmol). The mixture was stirred at RT for 2.5 h upon which the mixture was concentrated in vacuo to give the desired product, which was used directly in the next step without purification.

Aufarbeitung

  1. concentrationwas concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3b92ce2d54f94a298ff3bbf4bdd5e07d
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440961B2

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