HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(2-Chlorophenoxymethyl)oxirane → 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(2-Chlorophenoxymethyl)oxirane | HCID 137500 | — |
| Edukt | 1-(Piperidin-4-yl)-1,3-diazinan-2-one | HCID 15572666 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine | HCID 20368054 | — |
Reaktionsschritte
A solution of 9.2 g of 1-(o-chloro-phenoxy)-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydro-pyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from chloroform/petroleum ether to yield the 1-[3-(o-chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 150°-153° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04075335 |
| Quelldatensatz | uspto-grants-1978_02 |
| ORD ID | ord-6351b52759b7494a976e3ade071d5620 |
| Quellennotiz | uspto-grants-1978_02 |