p-Toluenesulfonic acid monohydrate → HCID 20368829, Verbindung

HRID 616706Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 616706
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:4]2[CH:3]=1.[OH2:20].[C:21]1(C)C=C[C:24](S(O)(=O)=O)=[CH:23][CH:22]=1>C(O)CCC>[CH2:21]([O:20][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:4]2[CH:3]=1)[CH2:22][CH2:23][CH3:24]

Komponenten

4

Edukt 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 12763962HCID 12763962, Verbindung

Produkt 1

HCID 20368829HCID 20368829, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 5-chloroimidazo[1,2-a]quinoline-2-carboxylate 2.75 g. (0.01 mole) and 40 mg. of p-toluenesulfonic acid monohydrate in 150 ml. of n-butanol is heated at 100° C. for 18 hours. The butanol is then removed under reduced pressure. The residue is dissolved in a small amount of chloroform and chromatographed on a silica gel column. The fractions containing the title compound are combined and evaporated to dryness. The product can be further purified by crystallization.

Aufarbeitung

  1. customThe butanol is then removed under reduced pressure
  2. dissolutionThe residue is dissolved in a small amount of chloroform
  3. customchromatographed on a silica gel column
  4. additionThe fractions containing the title compound
  5. customevaporated to dryness
  6. customThe product can be further purified by crystallization

Quellen und Nachweise

ORD-Eintrag
ord-7b2c0e2c2dc34d0e8e496aecb0c4dd0a
Quelldatensatz
uspto-grants-1978_02
Patentnummer
US04075343

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