Hydrochloric Acid → HCID 13707639, Verbindung
Reaktionsgleichung
[N+:1]([C:4]1C(=O)[O:6][C:7]2[C:12]([C:13]=1[OH:14])=[CH:11][CH:10]=[C:9]([O:15][CH3:16])[CH:8]=2)([O-:3])=[O:2].Cl>[OH-].[Na+]>[OH:6][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[CH:10]=[CH:11][C:12]=1[C:13](=[O:14])[CH2:4][N+:1]([O-:3])=[O:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-Nitro-4-hydroxy-7-methoxy coumarin (1.85 g, 0.078 m), prepared as described in D. R. Buckle, et al., J. Med. Chem., 18, 391 (1975), was stirred at room temperature in 5% aqueous sodium hydroxide (60 ml) for 20 hours. The mixture was slowly acidified with 5N HCl. The product was filtered off and sucked dry. Recrystallization from absolute ethanol gave pale yellow crystals (0.92 g, 56%), m.p. 138°-40° C.
Aufarbeitung
- filtrationThe product was filtered off
- customsucked dry
- customRecrystallization from absolute ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-0623de98b3024ab3a46b4b01a12c3934
- Quelldatensatz
- uspto-grants-1978_02
- Patentnummer
- US04076729
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