Pyrrolidine → 3-[1-(6-Ethoxy-2-morpholino-7-pyrrolidinylcarbonylmethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline

HRID 617167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 617167
[C:1]([CH2:4][O:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([N:22]3[CH2:27][CH2:26][CH:25]([N:28]4[C:37](=[O:38])[C:36]5[C:31](=[CH:32][CH:33]=[C:34]([CH3:39])[CH:35]=5)[N:30]([CH3:40])[C:29]4=[O:41])[CH2:24][CH2:23]3)=[N:11][C:12]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[N:13]2)=[CH:8][C:7]=1[O:42][CH2:43][CH3:44])(O)=[O:2].[NH:45]1[CH2:49][CH2:48][CH2:47][CH2:46]1>>[CH2:43]([O:42][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:6]=1[O:5][CH2:4][C:1]([N:45]1[CH2:49][CH2:48][CH2:47][CH2:46]1)=[O:2])[N:13]=[C:12]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)[N:11]=[C:10]2[N:22]1[CH2:27][CH2:26][CH:25]([N:28]2[C:37](=[O:38])[C:36]3[C:31](=[CH:32][CH:33]=[C:34]([CH3:39])[CH:35]=3)[N:30]([CH3:40])[C:29]2=[O:41])[CH2:24][CH2:23]1)[CH3:44]

Komponenten

3

Edukt 2

HCID 31268PyrrolidineHCID 21851265HCID 21851265, Verbindung

Produkt 1

HCID 218512213-[1-(6-Ethoxy-2-morpholino-7-pyrrolidinylcarbonylmethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazolineAusbeute 15 %

Versuchsvorschrift

The same procedure as in Example 57 was repeated, using 300 mg (0.50 mmol) of Compound 56 obtained in Example 56, except that pyrrolidine was used in place of isopropylamine, to give 48 mg (yield: 15%) of Compound 58 as white crystals.

Quellen und Nachweise

ORD-Eintrag
ord-1ed6f585f205431d8a1af9728fe374ef
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05948784

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