3,5-Dibromopyridine N-oxide → 3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide

Reaktionsgleichung

Br[C:2]1[CH:3]=[N+:4]([O-:9])[CH:5]=[C:6]([Br:8])[CH:7]=1.[CH3:10][N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][OH:17]>>[CH3:10][N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][O:17][C:2]1[CH:3]=[N+:4]([O-:9])[CH:5]=[C:6]([Br:8])[CH:7]=1

Komponenten

Edukt 2

HCID 6200033,5-Dibromopyridine N-oxide

HCID 643492(2S)-1-Methyl-2-pyrrolidinemethanol

Produkt 1

HCID 213096723-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide

Versuchsvorschrift

A sample of 3,5-dibromopyridine-N-oxide (prepared according to the method of Y. Tamura et al., Heterocycles, 15:871-874 (1981)) is reacted with (S)-(-)-1-methyl-2-pyrrolidinemethanol according to the procedure of Example 3a, and the product is purified by chromatography on silica gel.

Aufarbeitung

customthe product is purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag: ord-aff1e832d66e4ff49676770e755fcc3b
Quelldatensatz: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05948793

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