Thionyl Chloride → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester
Reaktionsgleichung
[N:1]1[CH:6]=[C:5]([C:7]([O-])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH3:13])=[O:11].S(Cl)([Cl:16])=O>>[C:10]([C:2]1[CH:3]=[CH:4][C:5]([C:7]([Cl:16])=[O:8])=[CH:6][N:1]=1)([O:12][CH3:13])=[O:11]Komponenten
3
Versuchsvorschrift
In step a, the carboxylic acid functionality of the appropriate 2,5-pyridinedicarboxylic acid, 2-methyl ester 10 (Nippon Kagaku Zasshi, 1967, 88, 563) is converted to its acid chloride using techniques and procedures well known and appreciated by one of ordinary skill in the art, such as thionyl chloride, to give the corresponding 6-carbomethoxynicotinoyl chloride 11.
Quellen und Nachweise
- ORD-Eintrag
- ord-12710f0f2f89454fb66fb185cd6524b5
- Quelldatensatz
- uspto-grants-1999_09
- Patentnummer
- US05948886
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