4-[3-(2-Pyrazinecarbonylamino)propylthio]pyridine → 4-[3-(2-Pyrazinecarbonylamino)propylthio]pyridine dihydrochloride

HRID 6176

Reaktionsgleichung

Reaktionsgleichung von HRID 6176
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:9][CH2:10][CH2:11][CH2:12][S:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)=[O:8].[ClH:20].CO>CO>[ClH:20].[ClH:20].[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:9][CH2:10][CH2:11][CH2:12][S:13][C:14]1[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=1)=[O:8]

Komponenten

4

Edukt 2

HCID 152315024-[3-(2-Pyrazinecarbonylamino)propylthio]pyridineHCID 21893726Hydrochloride methanol

Produkt 1

HCID 190791634-[3-(2-Pyrazinecarbonylamino)propylthio]pyridine dihydrochlorideAusbeute 85,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 704.5 mg (2.57 mmol) of 4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine in 30 ml of methanol, 70 ml of 10% hydrochloric acid-methanol was added, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off and the residue was purified by recrystallization (solvent: ethanol-ether) to give 842.4 mg of the desired compound (85.6% yield, pale yellow crystals).

Aufarbeitung

  1. distillationThe solvent was distilled off
  2. customthe residue was purified by recrystallization (solvent: ethanol-ether)

Quellen und Nachweise

ORD-Eintrag
ord-7c0a9d74a2794bf09aa140d9698f4f5f
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05246948

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