tert-Butyl isocyanate → 3-Tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(dimethylamino)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea

HRID 617931

Reaktionsgleichung

Reaktionsgleichung von HRID 617931
[NH2:1][C:2]1[C:3]([C:19]2[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:26])=[CH:4][C:5]2[CH:10]=[N:9][C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]([CH3:17])[CH3:16])=[N:7][C:6]=2[N:18]=1.[C:27]([N:31]=[C:32]=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([NH:31][C:32]([NH:1][C:2]1[C:3]([C:19]2[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:26])=[CH:4][C:5]2[CH:10]=[N:9][C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]([CH3:17])[CH3:16])=[N:7][C:6]=2[N:18]=1)=[O:33])([CH3:30])([CH3:29])[CH3:28]

Komponenten

3

Edukt 2

HCID 62412tert-Butyl isocyanateHCID 53281386-(2,6-dichlorophenyl)-2-N-[3-(dimethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine

Produkt 1

HCID 53281393-Tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(dimethylamino)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea

Versuchsvorschrift

Following the procedure of Example 21, 1.62 g of 7-amino-6-(2,6-dichlorophenyl)-2-(3-dimethylamino-propylamino)-pyrido[2,3-d]pyrimidine from Example 27 was reacted with 0.48 g of t-butyl isocyanate to give the title compound; mp gradually dec above 130° C.

Quellen und Nachweise

ORD-Eintrag
ord-7013e5535a2f460db3dcc240ffdb06ae
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952342

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