tert-Butyl isocyanate → 1-[2-Amino-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

HRID 617972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 617972
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[C:9]1[C:19]([NH2:20])=[N:18][C:12]2[N:13]=[C:14]([NH2:17])[N:15]=[CH:16][C:11]=2[CH:10]=1.[C:21]([N:25]=[C:26]=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[NH2:17][C:14]1[N:15]=[CH:16][C:11]2[CH:10]=[C:9]([C:3]3[C:2]([Br:1])=[CH:7][CH:6]=[CH:5][C:4]=3[Br:8])[C:19]([NH:20][C:26]([NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:27])=[N:18][C:12]=2[N:13]=1

Komponenten

3

Edukt 2

HCID 62412tert-Butyl isocyanateHCID 53281206-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Produkt 1

HCID 53281211-[2-Amino-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Versuchsvorschrift

The title compound was prepared from 0.25 g of 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 60 and 0.077 mL of tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc to afford the pure product; mp >300° C. (dec).

Aufarbeitung

  1. customThe product was purified by MPLC
  2. washeluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc
  3. customto afford the pure product

Quellen und Nachweise

ORD-Eintrag
ord-ce0745359a9942aea8200d4f0c00fab6
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952342

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