3',4',5'-Trimethoxyacetophenone → (E)-3-(6-Nitroindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one

HRID 618112Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 618112
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[N+:16]([C:19]1[CH:27]=[C:26]2[C:22]([C:23]([CH:28]=O)=[CH:24][NH:25]2)=[CH:21][CH:20]=1)([O-:18])=[O:17]>>[N+:16]([C:19]1[CH:27]=[C:26]2[C:22]([C:23](/[CH:28]=[CH:14]/[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)=[O:15])=[CH:24][NH:25]2)=[CH:21][CH:20]=1)([O-:18])=[O:17]

Komponenten

3

Edukt 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 52100766-nitro-1H-indole-3-carbaldehyde

Produkt 1

HCID 21850294(E)-3-(6-Nitroindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-oneAusbeute 1,1 %

Versuchsvorschrift

Substantially the same procedure as in Example 21 was repeated using 3',4',5'-trimethoxyacetophenone (1.25 g) and 6-nitroindole-3-carboxaldehyde (1.13 g) except that the obtained product was further purified by preparative HPLC, that the eluting solution was cooled, and that the precipitated crystals were collected by filtration, to give Compound 34 (26 mg).

Aufarbeitung

  1. customwas further purified by preparative HPLC, that the eluting solution
  2. temperaturewas cooled
  3. filtrationthat the precipitated crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b5d594092288441b837e6e6e11286f03
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952355

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