Piperidine → 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one

HRID 618131

Reaktionsgleichung

Reaktionsgleichung von HRID 618131
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11](=[O:13])[CH3:12].[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([CH:23]=O)=[CH:15]1.N1CCCCC1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11](=[O:13])[CH:12]=[CH:23][C:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][CH:15]=1

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 10256Indole-3-CarboxaldehydeHCID 709912',5'-Dimethoxyacetophenone

Produkt 1

HCID 541569131-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-oneAusbeute 44 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2',5'-Dimethoxyacetophenone (1.80 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 72 hours. The precipitated crystals were collected by filtration, and the obtained crude crystals were recrystallized from ethanol to give Compound 89 (1.35 g).

Aufarbeitung

  1. temperatureby heating
  2. temperatureunder reflux for 72 hours
  3. filtrationThe precipitated crystals were collected by filtration
  4. customthe obtained crude crystals
  5. customwere recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-05fe39220067459285c6760684758e9b
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952355

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