Trifluoroacetic acid → Glycyl-2(s)-phenylsulfonamido-beta-alanine t-butyl ester trifluoroacetate salt

HRID 618136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 618136
[C:1]([O:5][C:6](=[O:31])[C@@H:7]([NH:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:24])=[O:23])[CH2:8][NH:9][C:10](=[O:20])[CH2:11][NH:12]C(OC(C)(C)C)=O)([CH3:4])([CH3:3])[CH3:2].[C:32]([OH:38])([C:34]([F:37])([F:36])[F:35])=[O:33]>C(Cl)Cl>[F:35][C:34]([F:37])([F:36])[C:32]([OH:38])=[O:33].[C:1]([O:5][C:6](=[O:31])[C@@H:7]([NH:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:24])=[O:23])[CH2:8][NH:9][C:10](=[O:20])[CH2:11][NH2:12])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86754468N-Boc-glycyl-2(S)-phenylsulfonamido-beta-alanine t-butvl ester

Produkt 1

HCID 86754466Glycyl-2(s)-phenylsulfonamido-beta-alanine t-butyl ester trifluoroacetate salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-15 °C

Versuchsvorschrift

Protected amide 1-6 (576 mg, 1.26 mmol) was dissolved in 6.3 mL CH2Cl2, cooled to -15° C., and TFA (6.3 mL) was added. After 25 min the reaction was concentrated, providing amine 1-7.

Aufarbeitung

  1. concentrationAfter 25 min the reaction was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-b04a2f7842224c0bbf9556b37396dc8e
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952306

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