Glycine ethyl ester → 3-(4-t-Butoxycarbonyl-1-piperazinyl)benzoyl glycine
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=2)[C:17](O)=[O:18])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O:25][C:26](=[O:29])[CH2:27][NH2:28])C>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=2)[C:17]([NH:28][CH2:27][C:26]([OH:25])=[O:29])=[O:18])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
The acid 16-3 was coupled with glycine ethyl ester followed by hydrolysis of the resulting ester using previously described chemistry to yield 17-1.
Aufarbeitung
- customto yield 17-1
Quellen und Nachweise
- ORD-Eintrag
- ord-9c0aa2c641d34997a350f62b2f44d9e3
- Quelldatensatz
- uspto-grants-1999_09