HCID 18391989, Verbindung → (R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran

HRID 618281Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 618281
C([N:8]1[CH2:12][CH2:11][C@@H:10]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][O:15]2)[CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].CO>[O:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]1[O:13][C@@H:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

Komponenten

4

Edukt 1

HCID 18391989HCID 18391989, Verbindung

Produkt 1

HCID 18392016(R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyranAusbeute 122,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1-benzyl-3-(R)-tetrahydropyranyloxypyrolidine(8.78 g, 27.3 mmol) and Pearlman's catalyst (3.50 g) in MeOH (100 ml) was stirred under hydrogen atmosphere at rt for 4 h. After removal of the catalyst by Celite filtration, the filtrate was concentrated to give 5.74 g of clear light brown oil. This was used for the next reaction without purification.

Aufarbeitung

  1. customAfter removal of the catalyst
  2. filtrationby Celite filtration
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-b67e295ffa9640e4ae17ec6300c093c3
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952369

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