L-Glutamic Acid → [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid

HRID 618467

Reaktionsgleichung

Reaktionsgleichung von HRID 618467
N[C@H](C(O)=O)CC[C:5]([OH:7])=[O:6].[CH3:11][N:12]([C:26]1[CH:27]=[CH:28][C:29](C(N[C@H](C(O)=O)CCC(O)=O)=O)=[CH:30][CH:31]=1)[CH2:13][C:14]1[CH:15]=[N:16][C:17]2[N:23]=[C:22]([NH2:24])[N:21]=[C:20]([NH2:25])[C:18]=2[N:19]=1>>[NH2:24][C:22]1[N:21]=[C:20]([NH2:25])[C:18]2[C:17](=[N:16][CH:15]=[C:14]([CH2:13][N:12]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:5]([OH:7])=[O:6])[CH3:11])[N:19]=2)[N:23]=1

Komponenten

3

Edukt 2

HCID 33032L-Glutamic AcidHCID 126941Methotrexate

Produkt 1

HCID 70031183[[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid

Versuchsvorschrift

The title compound was prepared by carboxypeptidase G cleavage of glutamic acid from methotrexate as described in the literature (J. Med. Chem. 24, 1450-1455 (1981)). The yield of I obtained was virtually quantitative.

Aufarbeitung

  1. customThe yield of I obtained

Quellen und Nachweise

ORD-Eintrag
ord-c57135597378462697ba70197b1c3f36
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952499

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