4-Toluenesulfonyl chloride → 16-(p-Toluensulfonyloxy)hexadecanol

Beteiligte Stoffe

Reaktionsschritte

To a solution of 1.1 g of 1,16-dihydroxyhexadecane in 10 ml of dry pyridine 0.8 g of tosyl chloride was added. After 2 h mixture was concentrated diluted with 20 ml of acetone, 5 g of SiO2 was added and acetone was removed in vacuum. The solid was applied on SiO2 and eluted with pentane-ethyl acetate (2:1) to yield 748 mg (42%) of the compound of Structure 1 (C-101).

Herkunft & Nachweise