HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl butyrate → HCID 178456762, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl butyrate | HCID 12180 | — |
| Edukt | pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate | HCID 21847799 | — |
| Edukt | methyl (2S)-2-amino-4-(1H-1,2,3,4-tetrazol-5-yl)butanoate | HCID 178501500 | — |
| Produkt | HCID 178456762 | HCID 178456762 | — |
Reaktionsschritte
Using analogous procedures to those described in Example 1 pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate was reacted with methyl (2S)-2-amino-4-(tetrazol-5-yl)butyrate and the resultant methyl butyrate was hydrolysed to give 2- {p-{N-[1-(2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzamido}-4-(tetrazol-5-yl)butyric acid in 25% yields m.p. 207° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05955463 |
| Quelldatensatz | uspto-grants-1999_09 |
| ORD ID | ord-aa05807e024d4971adce787a3e9ef0e8 |
| Quellennotiz | uspto-grants-1999_09 |