Piperidine → Ethyl 4-(2-Piperidinoethoxy)benzoate
Reaktionsgleichung
CS([CH2:5][CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=1)(=O)=O.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C([O-])([O-])=O.[K+].[K+]>>[N:19]1([CH2:5][CH2:6][O:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
To a 25 mL round bottom flask with magnetic stirring and condenser and under nitrogen were added the following: the solution from step 2 containing about 10.0 mmol of ethyl 4-(2-methanesulfonylethoxy)benzoate, 2 mL (20 mmol) of piperidine, and 1.5 g K2CO3. The mixture was heated to 80° C. for 24 hours and then to 125° C. for an additional 24 hours to yield product. The yield was estimated to exceed 90%. The product was identical by chromatography and 1H-NMR to that found by published methods.