4-Morpholinopiperidine → 10,10-Dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-5-oxo-10,11-dihydro-5H-1,11-diaza-benzo[b]fluorene-2-carbonitrile

HRID 61889

Reaktionsgleichung

Reaktionsgleichung von HRID 61889
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:7]3[C:8](=[O:30])[C:9]4[CH:21]=[CH:20][C:19](OS(C(F)(F)F)(=O)=O)=[CH:18][C:10]=4[C:11]([CH3:17])([CH3:16])[C:12]=3[NH:13][C:14]=2[N:15]=1)#[N:2].[N:31]1([CH:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[CH3:17][C:11]1([CH3:16])[C:12]2[NH:13][C:14]3[N:15]=[C:3]([C:1]#[N:2])[CH:4]=[CH:5][C:6]=3[C:7]=2[C:8](=[O:30])[C:9]2[CH:21]=[CH:20][C:19]([N:40]3[CH2:41][CH2:42][CH:37]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)[CH2:38][CH2:39]3)=[CH:18][C:10]1=2

Komponenten

3

Edukt 2

HCID 7957244-MorpholinopiperidineHCID 86663828Trifluoromethanesulfonic acid 2-cyano-10,10-dimethyl-5-oxo-10,11-dihydro-5H-1,11-diaza-benzo[b]fluoren-8-yl ester

Produkt 1

HCID 6683463910,10-Dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-5-oxo-10,11-dihydro-5H-1,11-diaza-benzo[b]fluorene-2-carbonitrile

Versuchsvorschrift

According to the method used for synthesizing Compound B2-1, trifluoromethanesulfonic acid 2-cyano-10,10-dimethyl-5-oxo-10,11-dihydro-5H-1,11-diaza-benzo[b]fluoren-8-yl ester was introduced with 4-morpholin-4-yl piperidine to obtain the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-17919cd48e394dcbb9dbe357b3293765
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440922B2

Verknüpfte Notizen

Wird geladen…