Potassium Hydroxide → 2-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid

HRID 61894Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 61894
C([O:3][C:4](=[O:16])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[N:9]=1)([CH3:7])[CH3:6])C.[OH-].[K+]>CO>[CH3:15][O:14][C:10]1[N:9]=[C:8]([C:5]([CH3:7])([CH3:6])[C:4]([OH:16])=[O:3])[CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 668349252-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester

Produkt 1

HCID 668349942-(6-Methoxypyridin-2-yl)-2-methylpropanoic acidAusbeute 76,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester (5.33 g) was dissolved in methanol (200 ml), added with 5 N aqueous solution of potassium hydroxide (25 ml), and then stirred under reflux. The reaction mixture was concentrated and neutralized with 2 N hydrochloric acid. The precipitated matters were collected by filtration and dried to obtain the title compound (3.55 g).

Aufarbeitung

  1. temperatureunder reflux
  2. concentrationThe reaction mixture was concentrated
  3. filtrationThe precipitated matters were collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-68ac0fb7778f4719bde87654e031adc3
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440922B2

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