1-(3-(Benzyloxy)phenyl)-2-bromoethanone → 4-[3-(Benzyloxy)phenyl]-1,3-thiazol-2-amine hydrobromide

https://huagongshe.com/reaction/619080

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(3-(Benzyloxy)phenyl)-2-bromoethanone	HCID 88031	—
Edukt	Thiourea	HCID 2723790	—
Lösungsmittel	Methanol	HCID 887	—
Produkt	4-[3-(Benzyloxy)phenyl]-1,3-thiazol-2-amine hydrobromide	HCID 16495478	—

Reaktionsbedingungen

Temperatur	0 °C

Reaktionsschritte

A solution of 22.5 g of 2-bromo-1-(3-benzyloxy-phenyl)-ethanone in 150 ml of methanol was treated at room temperature with 7.8 g of thiourea and boiled for 1 hour. 16.1 g of 4-(3-benzyloxy-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05958910
Quelldatensatz	uspto-grants-1999_09
ORD ID	ord-d890b3c21f4a41788064f13ffdf142bb
Quellennotiz	uspto-grants-1999_09