Chlorosuccinimide → 2-Amino-5-chloro-3-methylbenzoic acid

Temperatur

100 °C

To a solution of 2-amino-3-methylbenzoic acid (Aldrich, 15.0 g, 99.2 mmol) in N,N-dimethylformamide (50 mL) was added N-chlorosuccinimide (13.3 g, 99.2 mmol) and the reaction mixture was heated to 100° C. for 30 minutes. The heat was removed, the reaction was cooled to room temperature and let stand overnight. The reaction mixture was then slowly poured into ice-water (250 mL) to precipitate a white solid. The solid was filtered and washed four times with water and then taken up in ethyl acetate (900 mL). The ethyl acetate solution was dried over magnesium sulfate, evaporated under reduced pressure and the residual solid was washed with ether to afford the desired intermediate as a white solid (13.9 g).

1. customThe heat was removed
2. temperaturethe reaction was cooled to room temperature
3. additionThe reaction mixture was then slowly poured into ice-water (250 mL)
4. customto precipitate a white solid
5. filtrationThe solid was filtered
6. washwashed four times with water
7. dry with materialThe ethyl acetate solution was dried over magnesium sulfate
8. customevaporated under reduced pressure
9. washthe residual solid was washed with ether

ORD-Eintrag

ord-ba5793cf0433421a91c24201c50db34d

Quelldatensatz

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09445593B1