Potassium Carbonate → 4-(5-Isoquinolylsulfanyl)-3-nitroaniline

HRID 619722

Reaktionsgleichung

Reaktionsgleichung von HRID 619722
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].F[C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][C:20]=1[N+:26]([O-:28])=[O:27]>CN(C=O)C>[CH:1]1[C:10]2[C:5](=[C:6]([S:11][C:19]3[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][C:20]=3[N+:26]([O-:28])=[O:27])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 677684-Fluoro-3-nitroanilineHCID 110519635-Isoquinolinethiol

Produkt 1

HCID 218469094-(5-Isoquinolylsulfanyl)-3-nitroanilineAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

5-Isoquinolinethiol 1.00 g (6.2 mmol) was dissolved in DMF 14 ml, potassium carbonate 1.01 g (7.3 mmol) and 4-fluoro-3-nitroaniline 0.96 g (6.1 mmol) were added and the mixture was heated with stirring for 2 hours at 100° C. The reaction solution was concentrated under reduced pressure, the resulting residue was washed with water to obtain 4-(5-isoquinolylsulfanyl)-3-nitroaniline 1.75 g (96.5%).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe resulting residue was washed with water

Quellen und Nachweise

ORD-Eintrag
ord-318b0d5941c04fb2a4d3d90fcc4e93c2
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05959107

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