Potassium Carbonate → 4-Chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline

HRID 619729

Reaktionsgleichung

Reaktionsgleichung von HRID 619729
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:18][C:19]1[C:25](Cl)=[CH:24][C:22]([NH2:23])=[C:21]([N+:27]([O-:29])=[O:28])[CH:20]=1>CN(C=O)C>[Cl:18][C:19]1[C:25]([S:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)=[CH:24][C:22]([NH2:23])=[C:21]([N+:27]([O-:29])=[O:28])[CH:20]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 811494,5-Dichloro-2-nitroanilineHCID 110519635-Isoquinolinethiol

Produkt 1

HCID 218469034-Chloro-5-(5-isoquinolylsulfanyl)-2-nitroanilineAusbeute 98,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

5-Isoquinolinethiol 500 mg (3.1 mmol) was dissolved in DMF 15 ml, potassium carbonate 830 mg (6.0 mmol) and 4,5-dichloro-2-nitroaniline 620 mg (3.0 mmol) were added, and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and the resulting precipitates were collected and washed with water to give 4-chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline 980 mg (98.4%).

Aufarbeitung

  1. customthe resulting precipitates
  2. customwere collected
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-2aa0d5973a264f50a9117edd28e1e3fd
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05959107

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