Hydrochloric Acid → 4-(3-Amino-2-oxopyrrolidine-1-ylmethyl)thiophene-2-carbonitrile hydrochloride

HRID 619837Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 619837
C(OC(=O)[NH:7][CH:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]#[N:20])[S:16][CH:15]=2)[C:9]1=[O:21])(C)(C)C.[ClH:23]>CCOC(C)=O>[ClH:23].[NH2:7][CH:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]#[N:20])[S:16][CH:15]=2)[C:9]1=[O:21]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 53990976[1-(5-Cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-yl]carbamic acid tert-butyl ester

Produkt 1

HCID 193510444-(3-Amino-2-oxopyrrolidine-1-ylmethyl)thiophene-2-carbonitrile hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

[1-(5-Cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-yl]carbamic acid tert-butyl ester (4 g, 13.8 mmol) is added to a solution of 100 mL of EtOAc sat. with HCl gas at 0° C. After 3 hours, the solution is concentrated. The title compound (3.3 g, 13.5 mmol) is obtained as a white solid.

Aufarbeitung

  1. concentrationthe solution is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-61b3f509eb2546a3ae3cc5eb17f7c04f
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05958918

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