Potassium Carbonate → 4-(N-4-hydroxybutyl-N-butylamino)benzaldehyde

HRID 6200

Reaktionsgleichung

Reaktionsgleichung von HRID 6200
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH2:10]([NH:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[OH:19][CH2:18][CH2:17][CH2:16][CH2:15][N:14]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[CH2:10][CH2:11][CH2:12][CH3:13]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 206691-Butanol, 4-(butylamino)-HCID 680234-Fluorobenzaldehyde

Produkt 1

HCID 197950944-(N-4-hydroxybutyl-N-butylamino)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

To a three neck flask fitted with a mechanical stirrer, a thermometer, and a condenser, is added 124 g (1 mole) of 4-fluorobenzaldehyde, 145.3 g (1 mole) of N-butyl-N-4-hydroxybutylamine, 138.2 g (1 mole) of anhydrous potassium carbonate, and dimethylsulfoxide. The mixture is then heated at 95° C. until the reaction is complete. After cooling to room temperature, the solution is poured into a four-fold excess of ice water, and the solid product is collected by filtration and purified by recrystallization from tetrahydrofuran/benzene.

Aufarbeitung

  1. customTo a three neck flask fitted with a mechanical stirrer
  2. temperatureAfter cooling to room temperature
  3. filtrationthe solid product is collected by filtration
  4. custompurified by recrystallization from tetrahydrofuran/benzene

Quellen und Nachweise

ORD-Eintrag
ord-4683026ba7114d0ab4a570be14f1d8a7
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05247042

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