Ammonia → 1-Isopropyl-2-chloromethylbenzimidazole

HRID 620028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 620028
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11])([CH3:3])[CH3:2].[Cl:12][CH2:13][C:14](O)=O.N>Cl>[CH:1]([N:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:11]=[C:14]1[CH2:13][Cl:12])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 300Chloroacetic AcidHCID 105587871-N-(propan-2-yl)benzene-1,2-diamine

Produkt 1

HCID 212484181-Isopropyl-2-chloromethylbenzimidazoleAusbeute 64,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

N-isopropyl-o-phenylenediamine (2.8 g, 18.6 mmol), which is a known compound, was reacted with monochloroacetic acid (2.64 g, 28 mmol) in hydrochloric acid. The reaction mixture was made to weak by alkaline alkali with aqueous ammonia and the obtained oily material was refined in a usual manner to give the title intermediate (2.5 g, 12 mmol).

Quellen und Nachweise

ORD-Eintrag
ord-9a9dcfe126da47e186ba1a05709c8a76
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04818761

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