1-Naphthaleneacetonitrile → 8-Piperidino-2-(1-naphthyl)-octanenitrile

Beteiligte Stoffe

Reaktionsschritte

3.9 g of sodium amide are added in small quantities to 16.7 g of 1-naphthyl-acetonitrile in solution in 200 ml of anhydrous ether. After 2 hours of heating to reflux, 20.5 g of 6-piperidino-1-chloro-hexane are added and heating is continued to reflux for another 5 hours. Then, using the conventional methods, 30 g of product are isolated.

Herkunft & Nachweise