2-Isopropylphenyl isothiocyanate → 1-(2-isopropylphenyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea

HRID 62057Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 62057
[F:1][C:2]([F:23])([F:22])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[N:13][C:12]([C:15]3[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=3)=[N:11]2)=[CH:6][CH:5]=1.[CH:24]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]=[C:34]=[S:35])([CH3:26])[CH3:25]>O1CCCC1>[CH:24]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33][C:34]([NH:19][C:18]1[CH:20]=[CH:21][C:15]([C:12]2[N:13]=[CH:14][N:10]([C:7]3[CH:6]=[CH:5][C:4]([O:3][C:2]([F:1])([F:22])[F:23])=[CH:9][CH:8]=3)[N:11]=2)=[CH:16][CH:17]=1)=[S:35])([CH3:26])[CH3:25]

Komponenten

4

Edukt 2

HCID 1420522-Isopropylphenyl isothiocyanateHCID 578244904-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)aniline

Produkt 1

HCID 1186752161-(2-isopropylphenyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thioureaAusbeute 45,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)aniline (0.10 g, 0.31 mmol) in tetrahydrofuran (5 mL) was added 1-isopropyl-2-isothiocyanatobenzene (0.10 g, 0.56 mmol). The solution was heated to reflux for 24 hours The solvent was removed under reduced pressure, then triturated with methanol to generate a white solid which was filtered and air-dried to provide the title compound (0.070 g, 45%).

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux for 24 hours The solvent
  3. customwas removed under reduced pressure
  4. customtriturated with methanol
  5. filtrationwas filtered
  6. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-36ca211cf3384247bb987b6547225526
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09445594B2

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