Hydrochloric Acid → 2-(p-Nitrophenoxy)-myristic acid

HRID 620702Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 620702
C([O:3][C:4](=[O:28])[CH:5]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])C.C(OC(=O)C(OC1C=CC=C([N+]([O-])=O)C=1)CCCCCCCCCCCC)C.[OH-].[Na+].Cl>C(O)C>[N+:25]([C:22]1[CH:21]=[CH:20][C:19]([O:18][CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:4]([OH:28])=[O:3])=[CH:24][CH:23]=1)([O-:27])=[O:26]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14122414Ethyl 2-(3-nitrophenoxy)tetradecanoateHCID 54095639Ethyl 2-(4-nitrophenoxy)tetradecanoate

Produkt 1

HCID 37465002-(p-Nitrophenoxy)-myristic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 980 g of 2-(p-nitrophenoxy)-myristic acid ethyl ester (synthesized analogously to the 2-(m-nitrophenoxy)-myristic acid ethyl ester of Preparation 1), 375 ml of 10N sodium hydroxide, and 1500 ml of ethanol is stirred for 1 h at room temperature and next acidified with 5000 ml of 1N hydrochloric acid. The resulting precipitate is filtered off, rinsed with water until neutral, and dried. The product (845 g) was recrystallized from n-hexane.

Aufarbeitung

  1. filtrationThe resulting precipitate is filtered off
  2. washrinsed with water until neutral, and
  3. customdried
  4. customThe product (845 g) was recrystallized from n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-a866a4cb93004cd1b249373b89c0efd7
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04822729

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