2-(Bis(methylsulfanyl)methylidene)propanedinitrile → 5-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole

HRID 620803

Reaktionsgleichung

Reaktionsgleichung von HRID 620803
[C:1]([C:3]([C:9]#[N:10])=[C:4](SC)[S:5][CH3:6])#[N:2].[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[CH2:16][NH:17][NH2:18]>C(O)C>[NH2:10][C:9]1[N:17]([CH2:16][C:15]2[CH:19]=[CH:20][CH:21]=[C:13]([C:12]([F:22])([F:23])[F:11])[CH:14]=2)[N:18]=[C:4]([S:5][CH3:6])[C:3]=1[C:1]#[N:2]

Komponenten

4

Edukt 2

HCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrileHCID 599698((3-(Trifluoromethyl)phenyl)methyl)hydrazine

Produkt 1

HCID 140710225-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazoleAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

8.5 g (0.05 mol) of 1,1-dicyano-2,2-bis(methylthio)-ethylene and 9.5 g (0.06 mol) of 3-trifluoromethylbenzyl-hydrazine (compare DE-OS (German Published Specification) No. 2,230,675) are stirred in 100 ml of ethanol at 20° C. for 15 hours. For working up, the solvent is removed in vacuo and the residue is triturated with petroleum ether. Filtration with suction gives 12.4 g (80% of theory) of 5-amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole of melting point 142° C.

Aufarbeitung

  1. customthe solvent is removed in vacuo
  2. customthe residue is triturated with petroleum ether
  3. filtrationFiltration with suction

Quellen und Nachweise

ORD-Eintrag
ord-de997f3e971c4dd9aecbe41bad4dd182
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04822810

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