2-Mercaptoethanol → 3-(2-Chloroethyl)-5,6-dihydro-1,4-oxathiin

A mixture of the 3,5-dichloro-2-pentanone (39 g., 0.24 mole) and 2-mercaptoethanol (20 g., 0.26 mole) in toluene (250 ml) was stirred, and triethylamine (27 g., 0.27 mole) added dropwise thereto. After stirring overnight at ambient temperature, the mixture was washed with dilute hydrochloric acid and subsequently refluxed with p-toluenesulfonic acid (0.5 g.) with azeotropic removal of water for 4 hours. Upon cooling, the reaction mixture was washed with aqueous sodium bicarbonate, dried (magnesium sulfate), and the toluene removed to leave the product 3-(2-chloroethyl)-5,6-dihydro-1,4-oxathiin (bp. 62°-70°/0.025 mm) in 60% yield and 98% purity (G.C.). N.M.R. spectrum (Deuterchloroform) gave lambda values: 1.85 (3H,S) 2.3-2.65 (2H,t); 2.9-3.5 (2H,t); 3.95-3.7 (2H,t); 4.1-4.25 (2H,t).

1. stirringAfter stirring overnight at ambient temperature
2. washthe mixture was washed with dilute hydrochloric acid
3. temperaturesubsequently refluxed with p-toluenesulfonic acid (0.5 g.) with azeotropic removal of water for 4 hours
4. temperatureUpon cooling
5. washthe reaction mixture was washed with aqueous sodium bicarbonate
6. dry with materialdried (magnesium sulfate)
7. customthe toluene removed

ORD-Eintrag

ord-3b55fa7e3dfd495abd4277ce47da7530

Quelldatensatz

uspto-grants-1989_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04822813