3,5-Dimethoxyaniline → 9-(3,5-Dimethoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Beteiligte Stoffe

Reaktionsschritte

Prepared from VII and 3,5-dimethoxyaniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 98%; yellow solid; mp 248° C.; IR (KBr) νmax/cm−1 3242, 2940, 2837, 2223, 1711, 1647, 1578, 1455, 1419, 1383, 1357, 1306, 1265, 1205, 1144, 1058, 1046, 968, 943, 917, 833, 806; 1H NMR (300 MHz, DMSO-d6) δ 8.51 (d, 1H, J=9.0 Hz), 8.06 (s, 1H), 7.79 (d, 1H, J=9.0 Hz), 6.31 (m, 3H), 3.74 (s, 6H); HRMS calcd for C18H14N5O2S (M+H+): 364.0868, found 364.0856.

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