Hydrochloric Acid → HCID 21242901, Verbindung

HRID 621459Notizen

Reaktionsgleichung

C(N1CCC2C=CC(S([Cl:18])(=O)=O)=CC=2CC1)(=O)C.C(N1CCC2C=CC(SC)=CC=2CC1)(=O)C.C([N:38]1[CH2:44][CH2:43][C:42]2[CH:45]=[CH:46][C:47]([S:49]([CH3:51])=[O:50])=[CH:48][C:41]=2[CH2:40][CH2:39]1)(=O)C.Cl>>[ClH:18].[CH3:51][S:49]([C:47]1[CH:46]=[CH:45][C:42]2[CH2:43][CH2:44][NH:38][CH2:39][CH2:40][C:41]=2[CH:48]=1)=[O:50]

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 113467373-acetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonyl chloride

HCID 21242874HCID 21242874, Verbindung

HCID 21242882HCID 21242882, Verbindung

Produkt 1

HCID 21242901HCID 21242901, Verbindung

Versuchsvorschrift

Following the procedure of Examples 4 and 5, 3-acetyl-7-chlorosulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine is converted to 3-acetyl-7-methylthio-2,3,4,5-tetrahydro-1H-3-benzazepine and then to 3-acetyl-7-methylsulfinyl-2,3,4,5-tetrahydro-1H-3-benzazepine which is hydrolyzed with dilute hydrochloric acid to give 7-methylsulfinyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride.

Quellen und Nachweise

ORD-Eintrag: ord-20a6adb0b0ed4db3a4ef1b5258abd4fd
Quelldatensatz: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04824839

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