Hydrochloric Acid → HCID 12899415, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2Komponenten
3
Versuchsvorschrift
The thus-obtained 21 g of 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril are dispersed in 150 ml of 8N-hydrochloric acid. The dispersion is heated under reflux conditions for 3 hours and then cooled. The insoluble matter thus formed is separated by filtration, washed with water and dried, and recrystallized from methanol-water to obtain 14 g of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 212°-213° C.
Aufarbeitung
- temperatureThe dispersion is heated under reflux conditions for 3 hours
- temperaturecooled
- customThe insoluble matter thus formed
- customis separated by filtration
- washwashed with water
- customdried
- customrecrystallized from methanol-water
Quellen und Nachweise
- ORD-Eintrag
- ord-bcb1ac2323eb437aaf6c5a5e6f00ce41
- Quelldatensatz
- uspto-grants-1989_04
- Patentnummer
- US04824840
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