Ammonia → 2-Isopropyl-5-oxo-1-imidazolidineacetamide

HRID 621599Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 621599
[CH3:1][CH:2]([CH:4]1[NH:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]([O:13]CC)=O)[CH3:3].[NH3:16]>CO>[CH3:3][CH:2]([CH:4]1[NH:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]([NH2:16])=[O:13])[CH3:1]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 14618022Ethyl 2-isopropyl-5-oxo-1-imidazolidineacetate

Produkt 1

HCID 146180232-Isopropyl-5-oxo-1-imidazolidineacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

An ice cold solution of 3.8 g (0.018 mol) of ethyl 2-(1-methylethyl)-5-oxo-1-imidazolidineacetate in 100 ml of methanol was saturated with gaseous ammonia. The solution was stirred at room temperature overnight and the solvent was evaporated under reduced pressure, to give 2-(1-methylethyl)-5-oxo-1-imidazolidineacetamide (3.4 g) as a viscous oil (Rf 0.33; ethyl acetate/methanol 6:4; silica gel plates). Monohydrate of sulphate salt m.p. 64° C. resolidifying with final decomposition at 114°-118° C.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-92cbabc2112f4048ad0f955073673e94
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04824861

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