[CH3:1][C:2]1[O:6][C:5]([C:7](O)=[O:8])=[C:4]([O:10][CH:11]([CH3:13])[CH3:12])[C:3]=1[O:14][CH:15]([CH3:17])[CH3:16].C(N1C=CN=C1)(N1C=CN=C1)=O.C(N(CC)CC)C.[NH2:37][C:38]1[NH:42][N:41]=[N:40][N:39]=1.C(C1NN=NN=1)(=O)N>C(#N)C>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:37][C:38]2[NH:42][N:41]=[N:40][N:39]=2)=[O:8])=[C:4]([O:10][CH:11]([CH3:13])[CH3:12])[C:3]=1[O:14][CH:15]([CH3:17])[CH3:16]Following the procedure described in Example 120, 2.00 g (8.84 mmol) of the above carboxylic acid, 1.65 g (10.18 mmol, 1.15 equiv) of 1,1'-carbonyl diimidazole, 2.2 g (21.5 mmol, 2.4 equiv) of triethylamine, and 0.89 g (10.46 mmol, 1.18 equiv) of 5-aminotetrazole in refluxing (2.5 hours) acetonitrile (46 mL) is converted to the carbamoyltetrazole. Recrystallization from toluene afforded 0.75 g (2.73 g theo., 27%) of 5-methyl-3,4-diisopropoxy-N-1H-tetrazol-5-yl-2-furancarboxamide; mp 190°-192° C. (dec).
Wird geladen…
