Hydrochloric Acid → (3R)-3-carbamoyloxypyrrolidine hydrochloride

HRID 622444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 622444
[ClH:1].C(OC([N:9]1[CH2:13][CH2:12][C@@H:11]([O:14][C:15](=[O:17])[NH2:16])[CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C.C(Cl)Cl>[ClH:1].[C:15]([O:14][C@@H:11]1[CH2:12][CH2:13][NH:9][CH2:10]1)(=[O:17])[NH2:16]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 14254785(3R)-1-(t-butoxycarbonyl)-3-carbamoyloxypyrrolidine

Produkt 1

HCID 67938211(3R)-3-carbamoyloxypyrrolidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

15 ml of a 4M hydrogen chloride solution in ethyl acetate was added to a suspension of 3.00 g of (3R)-1-(t-butoxycarbonyl)-3-carbamoyloxypyrrolidine in 30 ml of methylene chloride, and the mixture was stirred for 30 minutes at 30° C. After completion of the reaction, the precipitated crystals were collected by filtration and washed with ether, giving 1.78 g of the title compound.

Aufarbeitung

  1. customAfter completion of the reaction
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-03c4d8b62c884fa0a2a82c68322cd43b
Quelldatensatz
uspto-grants-1988_09
Patentnummer
US04771046

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