2,3-Dihydro-1H-indole-7-sulfonamide → 1H-Indole-7-sulfonamide

HRID 622599Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 622599
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[S:10]([NH2:13])(=[O:12])=[O:11])[CH2:3][CH2:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[S:10]([NH2:13])(=[O:11])=[O:12])[CH:3]=[CH:2]1

Komponenten

4

Edukt 1

HCID 143467542,3-Dihydro-1H-indole-7-sulfonamide

Produkt 1

HCID 143467551H-Indole-7-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a slurry of activated manganese dioxide (20 g) in methylene chloride (200 ml) was added indoline-7-sulfonamide (4.3 g). The mixture was stirred at 25° C. for 24 hours. The solid was removed by filtration and the filtrate concentrated and hexane added until crystallization occurred. The pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.).

Aufarbeitung

  1. customThe solid was removed by filtration
  2. concentrationthe filtrate concentrated
  3. additionhexane added until crystallization
  4. customThe pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.)

Quellen und Nachweise

ORD-Eintrag
ord-27e80961296c430697cdaac0e4abb270
Quelldatensatz
uspto-grants-1988_09
Patentnummer
US04772313

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