1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → Methyl 4-morpholin-4-ylbutyl (2E)but-2-ene-1,4-dioate

HRID 623355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 623355
[C:1]([O:8][CH3:9])(=[O:7])/[CH:2]=[CH:3]/[C:4]([O-])=[O:5].Cl.C(N=C=NCCCN(C)C)C.[N:22]1([CH2:28][CH2:29][CH2:30][CH2:31][OH:32])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>ClCCl>[C:1]([O:8][CH3:9])(=[O:7])/[CH:2]=[CH:3]/[C:4]([O:32][CH2:31][CH2:30][CH2:29][CH2:28][N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)=[O:5]

Komponenten

5

Edukt 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 166412594-(4-Morpholinyl)-1-butanolHCID 21721168(E)-4-methoxy-4-oxobut-2-enoate

Produkt 1

HCID 71660813Methyl 4-morpholin-4-ylbutyl (2E)but-2-ene-1,4-dioate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Monomethyl fumarate (MMF) was reacted with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDAC) (1.2 eq) in dichloromethane (DCM) at ca. 0° C. 4-Morpholin-4-yl-butan-1-ol (1 eq) and 4-N,N-dimethylaminopyridine (DMAP) (catalytic amount) were added to the activated carboxylic acid. After the completion of the reaction, followed by the work-up of the reaction mixture, the title compound was isolated as a viscous-oil.

Aufarbeitung

  1. customAfter the completion of the reaction

Quellen und Nachweise

ORD-Eintrag
ord-ebe0b431102c4166816d2cd5819021d0
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09302977B2

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