Thionyl Chloride → 2-(Chloromethyl)-6-(2,2,2-trifluoroethoxy)pyridine
Reaktionsgleichung
[F:1][C:2]([F:14])([F:13])[CH2:3][O:4][C:5]1[N:10]=[C:9]([CH2:11]O)[CH:8]=[CH:7][CH:6]=1.S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:11][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]([O:4][CH2:3][C:2]([F:14])([F:13])[F:1])[N:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of (6-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol (0.32 g, 1.55 mmol, Step-3), thionyl chloride (0.23 mL, 3.10 mmol) in dichloromethane (16 mL) is stirred at room temperature for 1 hour. The organic solvent is concentrated under reduced pressure and dried to give 0.35 g (>99% yield) of the title compound as yellow oil. This material is used for the next reaction (Step-5) without further purification.
Aufarbeitung
- concentrationThe organic solvent is concentrated under reduced pressure
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-97249bdf871b43c78af58330f3b0fb72
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09302991B2
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