Isobutyramide → Methyl 2-isobutyramido-6-methylisonicotinate
Reaktionsgleichung
Cl[C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:13]([NH2:18])(=[O:17])[CH:14]([CH3:16])[CH3:15]>>[C:13]([NH:18][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6])(=[O:17])[CH:14]([CH3:16])[CH3:15]Komponenten
3
Versuchsvorschrift
The title compound is prepared in quantitative yield (1.27 g, yellow syrup) from methyl 2-chloro-6-methylisonicotinate (1.00 g, 5.39 mmol) and isobutyramide by the similar manner in Step-1 of Carboxylic acid-4.
Quellen und Nachweise
- ORD-Eintrag
- ord-035687bf00894351ab50b0a67b89379f
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09302991B2
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