Cyclopropanecarboxamide → Methyl 2-(cyclopropanecarboxamido)pyrimidine-4-carboxylate
Reaktionsgleichung
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][N:3]=1.[CH:12]1([C:15]([NH2:17])=[O:16])[CH2:14][CH2:13]1>>[CH:12]1([C:15]([NH:17][C:2]2[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][N:3]=2)=[O:16])[CH2:14][CH2:13]1Komponenten
3
Versuchsvorschrift
The title compound is prepared in quantitative yield (1.93 g, a pale yellow solid) from methyl 2-chloropyrimidine-4-carboxylate (1.50 g, 8.69 mmol) and cyclopropanecarboxamide by the similar manner in Step-1 of Carboxylic acid-4.
Quellen und Nachweise
- ORD-Eintrag
- ord-cd0932d17f7c4830b2c7075b30648345
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09302991B2
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