Methyl 2-chloropyridine-4-carboxylate → Methyl 2-(1-methylcyclopropanecarboxamido)isonicotinate
Reaktionsgleichung
Cl[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH3:12][C:13]1([C:16]([NH2:18])=[O:17])[CH2:15][CH2:14]1>>[CH3:12][C:13]1([C:16]([NH:18][C:2]2[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=2)[C:5]([O:7][CH3:8])=[O:6])=[O:17])[CH2:15][CH2:14]1Komponenten
3
Versuchsvorschrift
The title compound is prepared in 86% yield (0.30 g, a white solid) from methyl 2-chloroisonicotinate (0.25 g, 1.46 mmol) and 1-methylcyclopropanecarboxamide by the similar manner in Step-1 of Carboxylic acid-4.
Quellen und Nachweise
- ORD-Eintrag
- ord-651c8977760c49339621136fffc3dbac
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09302991B2
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