[3-(2,4-dihydroxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid t-butyl ester → 4-Isopropyl-6-[5-(4-morpholin-4-yl-phenylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol

HRID 623676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 623676
C(OC(=O)[N:7]([C:20]1[N:21]([C:25]2[CH:30]=[C:29]([CH:31]([CH3:33])[CH3:32])[C:28]([OH:34])=[CH:27][C:26]=2[OH:35])[N:22]=[N:23][CH:24]=1)[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH:31]([C:29]1[CH:30]=[C:25]([N:21]2[C:20]([NH:7][C:8]3[CH:9]=[CH:10][C:11]([N:14]4[CH2:15][CH2:16][O:17][CH2:18][CH2:19]4)=[CH:12][CH:13]=3)=[CH:24][N:23]=[N:22]2)[C:26]([OH:35])=[CH:27][C:28]=1[OH:34])([CH3:33])[CH3:32]

Komponenten

3

Edukt 1

HCID 131735186[3-(2,4-dihydroxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid t-butyl ester

Produkt 1

HCID 574046064-Isopropyl-6-[5-(4-morpholin-4-yl-phenylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diolAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21863450Trifluoroacetic acid methylene chlorideLösungsmittel

Versuchsvorschrift

A solution of the intermediate from Step E in DCM/TFA (1/1 5 ml) was stirred for 12 hours at RT. The reaction mixture was concentrated under reduced pressure and the crude reaction mixture was purified by column chromatography (DCM/MeOH: 95/5). The title compound was obtained as slightly brown solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude reaction mixture
  3. customwas purified by column chromatography (DCM/MeOH: 95/5)

Quellen und Nachweise

ORD-Eintrag
ord-6104a9e4cc994815ba91308fc49594dd
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09302998B2

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