tert-butyl 1-(2,4-dihydroxy-5-isopropylphenyl)-1H-1,2,3-triazol-5-yl(4-morpholinobenzyl)carbamate → 4-Isopropyl-6-[5-(4-morpholin-4-yl-benzylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol

HRID 623681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 623681
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]([CH:9]([CH3:11])[CH3:10])=[CH:4][C:3]=1[N:12]1[C:16]([N:17]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)=[CH:28][CH:27]=2)C(=O)OC(C)(C)C)=[CH:15][N:14]=[N:13]1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH:9]([C:5]1[CH:4]=[C:3]([N:12]2[C:16]([NH:17][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)=[CH:30][CH:31]=3)=[CH:15][N:14]=[N:13]2)[C:2]([OH:1])=[CH:7][C:6]=1[OH:8])([CH3:11])[CH3:10]

Komponenten

3

Edukt 1

HCID 117678674tert-butyl 1-(2,4-dihydroxy-5-isopropylphenyl)-1H-1,2,3-triazol-5-yl(4-morpholinobenzyl)carbamate

Produkt 1

HCID 574046074-Isopropyl-6-[5-(4-morpholin-4-yl-benzylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diolAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21863450Trifluoroacetic acid methylene chlorideLösungsmittel

Versuchsvorschrift

A solution of the intermediate from Step D in DCM/TFA (1/1, 5 ml) was stirred for 12 hours at RT. The reaction mixture was concentrated under reduced pressure and the crude reaction mixture was purified by column chromatography (DCM/MeOH: 95/5). The title compound was obtained as slightly brown solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude reaction mixture
  3. customwas purified by column chromatography (DCM/MeOH: 95/5)

Quellen und Nachweise

ORD-Eintrag
ord-a6543491e2134c5fab865797e63fae41
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09302998B2

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