Isoindoline → Methyl 5-(isoindoline-2-carboxamido)picolinate

HRID 624193Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624193
NC1C=CC([C:6]([NH:8]CCC)=[O:7])=CC=1.[CH2:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][NH:15]1.Cl.[CH2:24]1[C:32]2C(=C[C:29]([C:33]([O:35][CH3:36])=[O:34])=[CH:30][CH:31]=2)C[NH:25]1>>[CH2:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][N:15]1[C:6]([NH:8][C:32]1[CH:31]=[CH:30][C:29]([C:33]([O:35][CH3:36])=[O:34])=[N:25][CH:24]=1)=[O:7]

Komponenten

4

Edukt 3

HCID 422478IsoindolineHCID 4283444-amino-N-propylbenzamideHCID 19828495methyl 2,3-dihydro-1H-isoindole-5-carboxylate hydrochloride

Produkt 1

HCID 68752123Methyl 5-(isoindoline-2-carboxamido)picolinate

Versuchsvorschrift

The title compound was prepared as described in Example 272B, substituting methyl 5-aminopicolinate for 4-amino-N-propylbenzamide and isoindoline for methyl isoindoline-5-carboxylate hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-3b470846743b4fc9949efc54325f70fd
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09302989B2

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